Intermediate Us vs Uronema

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Dierks

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A TLDR of Uronema treatment options for quick reference:
  1. Formalin: Dose every 24 hours in a QT for 7-10 days. Dosage is as follows:
    * 0.9 ml per 10 gallons if dosing formalin WITH copper in the water
    * 1 ml per 10 gallons if dosing formalin WITHOUT copper in the water

  2. Chloroquine Phosphate: More info here

  3. Tea Tree Oil (best option for fish showing red sores)
    Bath:
    For One gallon of Saltwater add .76 ml (20ppm) of the Standard Melafix (DO NOT GET THE MARINE) for 15 minutes (We must get to the 10-minute mark to call the bath successful if the fish is doing well a 30-minute bath is ideal). Really get that air going in the water as well as this does indeed deplete the water of oxygen.

    How do you use it?

    You will have to give a bath every 48 hours for a total of 3 treatments. After the bath, the fish should go into a fresh tank with an antibiotic or Methylene Blue to help heal the wound as the uronema dies off and the open wound is exposed. So this means you will need two tanks/buckets and two sets of equipment to rotate between.

    (Or if you only have one QT to work with, I suggest doing the baths but adding metro and antibiotics to the QT post bath. The trifecta would be best into the tank to try and limit the reinfection and for the open wounds.)
More information:

I know this article is well past due, but with my schedule, I simply haven't had an opportunity to get around to writing this up. So with that being said here is what we know and an update on the progress of this whole crazy experiment.

As you all know I am a quarantine Vendor here, (Shameless Plug is Here if you want to check us out) and if you live in the United States you also most likely are aware of the Uronema problem we have here in our supply chain. Unfortunately, it feels like we can never get away from this crazy disease... I have done hours and hours of study on the subject to try and figure out what can we do to beat this thing. I know that there are ways out there that are tried and true but that discussion goes in circles when we start speaking of Formalin and Chloroquine phosphate. They both have their issues there is no question about it but they seem to be the best options we have against this nasty ciliate that can burrow deep inside the fish including getting into the bloodstream and getting all the way to the brain.

As of today when I write this Aquabiomics has confirmed that 19% of the tanks that they have tested do indeed have some sort of uronema. Does this mean that Uronema is in 19% of our tanks? No, because most likely if you are sending in a test to Aquabiomics you are having some sort of issue. So the test results are skewed but it does show that it is a very prevalent disease. The good news is that if your fish stay nice, clean, and healthy even if you have uronema in the tank it's not a death sentence. I will say this, if there is any fighting or nipping or really any sort of rock scraping that is when we get into the danger zone. So if you have uronema, eventually you will have to face it.

So... What can we do?
Well here are three ways to beat Urononema in my experience, the last being the newest and I find the most interesting! I would love to set up a list of fish that have been saved or lost by this treatment. I will ask for you all to post here results so we can really nail down if this is truly something that could work for you and see if we can ahead of this disease.

The first and Best Method I have found is Formalin... Yes, Formalin sucks for all the reasons we have discussed over and over on here and everyplace else. It is a very nasty chemical and if you are going to use formalin, use it very carefully. I will write up an article on how we use it here at the FisHotel, and again I understand the concerns as it has a lot of red flags if you don't use it carefully and respect it. But the truth is, it simply works... I have yet to have a fish slip through our latest use of formalin and that includes hundreds of fish. So for us, that is what is most important, We can not have anything slip through into your tanks.

How do you use it?
We use a low dosage of .9 ml per 10 Gallons only because we combine it with Copper. If you are to use it by itself Noga suggests that you use 1 ml per 10 Gallons.

The Second and good option is Chloroquine Phosphate... Yup, this is also a good option but it too has its pitfalls. Of course, if you are dosing a whole tank this is a great option but know that in most cases if the fish is showing red sores most likely this potion will not save those fish. You can't test for the levels so that is very frustrating. So ridding things that have to stay at certain levels is almost impossible but I have had ok success with it stopping the spread of uronema. Some fish react pretty badly to CP, and taking fish from copper to CP is risky at best as they seem to always stop eating at the very least. You Cant really know that you have dosed to much until the fish start acting really off so unless you are paying attention that can easily go unnoticed in our busy lives. So until we have a way to test what our levels are, this too isn't the perfect solution.


How do you use it?
@Humblefish has already taken care of you!
You can find the article here on how to use this powerful but hard-to-get drug. When we do use this medication we always use protocol #2 no matter if it's a new tank or an old one. I just feel like keeping it in a range is our best option as again we have no way of really knowing how much medication is in the water.

The Third and what we have been testing is Tea Tree Oil... I know, I will do it for you. :rolleyes::rolleyes::rolleyes::rolleyes:

Okay now that is out of the way, here is what we have found. I want to make this clear, this wasn't me, this was a Big group effort before everyone kind of got to busy. I know myself and @Humblefish had been trying to track down a study that showed oils curing uronema. But the problem was it doesn't seem to exist even though many studies refer back to it. So that started a 2-year journey to try and find this thing for me... I asked everyone!! Finally, I caught a break and was pointed to a paper that showed all the bar graphs from this notoriously hard-to-get study! I had everything we needed and sure enough, the ball started rolling. One of the vendors (@EAChris) started to give their newly acquired fish this tea tree oil bath and seemed to have pretty good results. But it was only a one-time bath so it didn't seem to take care of the issue completely. @Jposch started really ramping up the testing by giving fish multiple baths and I was doing the same. Lo and behold we felt that we were onto something. Seemed to be working!! It not only helped with uronema but also helped with bacterial issues. So, even when we are wrong here the tea tree oil seemed to help with any and all redness!


Here is the abstract that everyone references and what got this idea started.

How do you use it?
We will have to give a bath every other day for 3 treatments. After the bath, they will have to go into a fresh tank with an antibiotic or Methylene Blue to help heal the wound as the uronema dies off and the open wound is exposed. So this means you will need two tanks/buckets and two sets of equipment to rotate between.

Bath:
For One gallon of Saltwater add .76 ml (20 ppm) of the Standard Melafix (DO NOT GET THE MARINE) for 15 minutes (We must get to the 10-minute mark to call the bath successful, if the fish is doing well a 30-minute bath is ideal) Really get that air going in the water as well as this does indeed deplete the water of oxygen.

5001010.jpg


Things to look for --
Fish "falling Asleep": they will fall onto their sides sometimes and as long as they have been in the bath for over 10 minutes you can call it a successful bath, but we like to keep them in for really as long as they can tolerate it up to 30 minutes. The studies show we only need about 7 minutes to kill off Uronema exposed to TTO.
Fish Nose Diving - If you see your fish really start taking a dive (I have only seen this once with a Triggerfish) and can't lift themselves off the glass pull them ASAP.
Note: they may get a bit excited in the bath in the beginning and you will see them slowly calming down and even hang out at the bottom as they slowly fall asleep. This is all "normal" so look for the 15-minute stage or the above to pull the fish.

This treatment should help with both uronema and also bacterial issues.

I hope this helps and I hope this is a way to help heal your fish without the harsh chemicals, I know the folks in other countries may find this helpful as well as I know it's not as easy to get your hands on medication as it is here in the US. So that brings us to today... Of all of the fish, we have ever tested this on we have lost one fish... So we feel that it is safe enough to bring to the public.

*****We need your help by reporting back If you did the bath, on what fish and a picture of the fish before treatment would be helpful! We can then keep a tally of if it worked and if it is safe on all fish.****

Bath has been tested on the following fish:


Key:
Purple = Prophylactic Single Treatment (One Bath When Received, One Bath on Exit)
Green = No Issues Yellow = With Caution Red = Died

Bangaii Cardinal
x1
Barred Goby (Dartfish) x1
Blue Throat Fairy Wrasse x2
Brunneus Fairy Wrasse x1
Coral Hogfish x1
Copperband Butterfly x3 x7
Dusky Wrasse x2
Powder Brown Tang x2
Nebulous Wrasse x1
Niger Trigger x2
One Spot Foxface x1
Pearlscale butterfly x2
Pink Belly Wrasse x1
Raffle's Butterflyfish x1
Red Fin Fairy Wrasse x1
Scissortail Goby (Dartfish) x2
Swallowtail Angel x1
Squareback Anthias x5
Two Spot Bristletooth Tang x2
Yellow Candy Hogfish x1
Yellow Watchman Goby x7
Zigzag Wrasse x1
 
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Lachri

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I can't say for sure what worked on mine. Uronema was confirmed through a fecal test, no sores ever seen. Treatments included 1 ruby reef rally pro bath, Metro in water and food for 2 weeks, and phosphate chloroquine for 2 days (before they stopped eating it). Through this, they were going through HTTM. 3 TTO baths. The third bath was the hardest on them by far, but they lived. Tests continued being positive until about a week after I stopped the metro, and a week or two after the last TTO bath.
2 scissortail gobies (dartfish), 1 barred goby (dartfish), 1 bangaii cardinal. The dartfish had the hardest time after the last TTO bath. I was afraid I killed them that last treatment. That was a 16 min bath.

Most likely irrelevant info: I was doing 75% water changes every three days when I was not doing the full tank transfers, so there was no build up of crap in the water, even though I fed frozen food several times a day. Also, before I started getting consistent negative fecal results, I had started feeding garlic oil (trying to get one of the fish to eat, not relevant to the uronema). I don't think this cured them but I wonder if the garlic oil worked a bit like a laxative and helped push the parasites out easier with the help of other meds?
 

Dierks

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I had started feeding garlic oil
This was on the list of oils they tried and at 20ppm it did work if I recall correctly. But not the flavor, but the actual extract and then to a 5:1 ratio to thin it out with ethanal.
 

Lachri

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This was on the list of oils they tried and at 20ppm it did work if I recall correctly. But not the flavor, but the actual extract and then to a 5:1 ratio to thin it out with ethanal.
I know we use garlic in combination with other stuff for natural parasite treatment in people, but it's never the garlic alone on the products that work. Garlic isn't even the main ingredient on the list, so it got me thinking maybe it just helps push everything out of the body? I didn't do ANY research though, so it was just a fleeting theory.
 

stmilb2

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Any further thoughts on treating a display for prophylaxis during a fallow? I'd like to have an option to incorporate a uronema treatment empirically into fallow period for FOWLR tanks if we can.

Thus far, have dosed 25mg/gallon every other day for 12 days straight as per prior recs.
 

Oscarmk

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Wow this is a great write up! Surprised to see fishes with sores can actually survive with this threatment!. I’ll say I have never seen an open sore in a fish, but I had fish die from Uronema before that stage, in my case whole tank threatment with H2O2 seems to have done the trick (H2O2 is not an option with open sores), but now thet I am reading about the scratches putting you in the danger zone, well they certainly haven’t had one, so makes me wonder now 🤔, I think threatment worked but it isn’t confirmed with a Test.
 

mjreefs

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It would be interesting if there will be an in-tank treatment for Uronema using TTO. Also, it would be interesting if we can have dosage instructions for Melafix Marine and Melafix Pond. I currently use Melafix Pond (which is the more concentrated of the three if I'm not mistaken) as a coral dip.
 

Dierks

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Any further thoughts on treating a display for prophylaxis during a fallow? I'd like to have an option to incorporate a uronema treatment empirically into fallow period for FOWLR tanks if we can.

Thus far, have dosed 25mg/gallon every other day for 12 days straight as per prior recs.
FOWLR can use formalin, really the only thing I have found that works but it sounds like there may be other options on the horizon. (Not from me)

Thus far, have dosed 25mg/gallon every other day for 12 days straight as per prior recs.
Dosed what?
 

Dierks

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Wow this is a great write up! Surprised to see fishes with sores can actually survive with this threatment!. I’ll say I have never seen an open sore in a fish, but I had fish die from Uronema before that stage, in my case whole tank threatment with H2O2 seems to have done the trick (H2O2 is not an option with open sores), but now thet I am reading about the scratches putting you in the danger zone, well they certainly haven’t had one, so makes me wonder now 🤔, I think threatment worked but it isn’t confirmed with a Test.
the best example of about as far as we have gone and saved one is this guy:

The nice part about the TTO is that it will also help kill off lots of bacteria so that is a win, win. Nice to be wrong, since we always will be sometimes. Yet, the fish doesn't have to suffer because of our misdiagnosis.
 

Dierks

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Also, it would be interesting if we can have dosage instructions for Melafix Marine and Melafix Pond. I currently use Melafix Pond (which is the more concentrated of the three if I'm not mistaken) as a coral dip.
The problem with these is that the product spec/papers that are submitted have a range of how much TTO can be in each bottle. The standard as pictured and directed is 1% TTO... That is the reason behind us only using one kind. This is brand new and we need to eliminate as many variables as we cant to start.

I invite you to do what you will as all the information is out there so if you would like to start to test on fish and report back it would be useful information.
 

Dierks

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@Dierks Great write up! So would it be ideal to treat prophylactically with tto? Can do it every 48 hours alongside ttm or even hybrid ttm?
I dont think so... Its so new that I don't know if you should risk it? I am trying to collect data here so we all know the answers to the question on how safe it is and what does well. I have found that it is safe, but of course, I only have about 100-200 fish samples in as single bath.

I will say this of the big issued fish with this disease like Damsels, Chromis, Anthias, and some Large scaled Angelfish & Butterflyfish. (Copperbands come to mind)

The nice part is that you can start when you see it, just don't start late or we are going to miss the very tight window. Hope this helps
 
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itseng

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Great article, @Dierks and thank you so much! The article just comes at the right time for me. I've had two failed attempts at quarantining Lined Chromis, and I really want to get it right this time. About two months ago, I ordered 5 Lined Chromis from my local fish store, as they're not readily available in my area. I received a phone call from the store last weekend, informing me that my order had arrived, but that one fish had Ich and another had a red sore in the tank. The store also told me to pick up the fish this weekend, and I hope there are more than 5 for me to choose from. I've already ordered Standard Melafix online, and it will arrive at my place by Friday. In addition to that, I have Cooper Power, Tea Tree Oil, Formalin, Methylene Blue, and Metro ready.

I'm wondering what I should do when I quarantine the fish this weekend. I plan to do a Standard Melafix bath before putting them into my fresh QT. But what should I do next, as I know I will have to deal with Ich and uronema? Can I combine Cooper Power and Formalin on day one, or should I combine Cooper Power and Tea Tree Oil on day one? Or should I combine all three of them together? Please share your thoughts, and thanks in advance!
 

Dierks

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But what should I do next, as I know I will have to deal with Ich and uronema?
The Tea Tree oil will take care of the Uronema, I suggest adding this into TTM for your Ich. Or you can simply add the fish into copper after the TTO baths.

But because of this case, I would run TTM but instead of them clean run and antibiotic or MB so they heal between baths.

The schedule would be:
Day 0: Recieve fish - TTO Bath and into MB or Antibiotics if you have them (Stress guard might be available for you guys)
Day 1: Nothing
Day 2: Transfer - TTO Bath into MB or Antibiotics
Day 3: Nothing
Day 4: TTO Bath and into a tank to finish out the TTM.

Or... You can simply run formalin and copper together in a tank for 14 days and then into observation.
 

Dierks

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Can I combine Cooper Power and Formalin on day one, or should I combine Cooper Power and Tea Tree Oil on day one?
You can do all of them if you want but that is getting close to the edge I would think. They would be squeaky clean when they came out! This is what the Copperbands will have to deal with coming through the hotel... So I will have to report back. Or if you do, please report back!
 

itseng

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You can do all of them if you want but that is getting close to the edge I would think. They would be squeaky clean when they came out! This is what the Copperbands will have to deal with coming through the hotel... So I will have to report back. Or if you do, please report back!
@Dierks, Thank you very much! I feel confident and prepared now. I will definitely update on the outcome of the quarantine process. Once again, thank you for your valuable advice and support!
 

MrLargo

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the best example of about as far as we have gone and saved one is this guy:

The nice part about the TTO is that it will also help kill off lots of bacteria so that is a win, win. Nice to be wrong, since we always will be sometimes. Yet, the fish doesn't have to suffer because of our misdiagnosis.
You beat me to it, @Dierks ! YES, add a Swallowtail Angel to the successful treatment list. Thanks to this TTO method, we reversed the inflamed red sore from Uronema in 6 days! See the attached pics progression, as it started from a swollen bump, then red sore, and finally healed after 3 treatments. The scales never came back, but she was fully healed. Thanks again, for saving her!
 

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